4-acetamidophenoxyacetylhydrazide is synthesized from paracetamol which on reaction with various aldehyde gives Schiff bases. Schiff bases treated with mercaptoaceticacid to produce thiazolidinenone derivatives. The entire synthesized compound characterized by physical and analytical data. The chemical structures of synthesized compound were confirmed by means of IR, 1HNMR and MS. Antimicrobial activity of synthesized compounds evaluated by cup-plate method. Synthesized compound showed good antimicrobial activity.

Drugs are the critical element in health care. They must be manufactured to the highest quality level. End product testing by itself does not guarantee the quality of the product. Quality assurance technique must be used. In pharmaceutical industry, process validation performs this task, ensuring that the process does what it purport to do. Validation is one of the important steps in achieving and maintaining the quality of the final product. If each steps of production process is validated we can assure that the final product is of the best quality. Process validation also emphasizes the role of objective measures and statistical tools & analyses and emphasizes knowledge, detection, and control of variability and gives assurance on consistent of quality/productivity throughout life cycle of product. Validation is the tool which establishes a high degree of assurance that all processes meet their intended specifications. Hence pharmaceutical validation becomes significant in pharmaceutical industry. This overview summarizes the various aspects of pharmaceutical validation. This paper represents an introduction and general overview of process validation of pharmaceutical manufacturing process

Schizophrenia is blatantly the most dreadful psychotic disorder we need to pry in, given its prototype symptoms, complex etiology, pathophysiology and treatment approaches. Furthermore, people in prime of their lives fall target to schizophrenia. This study reveals the general description and discusses diverse modes of the disease. The study advances with more focus on the mechanistic pathways and not only the conventional Neurotransmitter/Receptor theories, rather on newer neurodevelopmental approaches such as genetic susceptibility i.e. NRG-1 and DISC-1 and its associate biomolecules FES-1, NUDEL & LIS-1 standing, reelin association, DNA Methylation, calcineurin hypothesis, prenatal and perinatal manifestations & viral infections. Further this article encompasses classification of the clinical symptoms into positive, negative and cognitive deficit symptoms followed by the therapy for a clinically diagnosed schizophrenic patient and discussion of common paradox of FGAs and SGAs, considering the better efficacy with lesser EPS. It concludes with the brief discussion on need of compliance for the schizophrenic patients and how SGA Depot Injections are helpful for patients with poor compliance.

In recent years, a no. of plants has been investigated and reported possessing medicinal values. Large body of evidence has accumulated to demonstrate promising potential of plants used in various traditional, complementary and alternative systems. The present review aimed to compile data on phytochemicals and promising ethnomedicinal valuse of Barleria prionitis L. (Acanthaceae) which have been established against various disease models using modern scientific methodologies and tools.

Synthesis and characterization of 2-[(8-hydroxyquinolinyl)-5-aminomethyl]-3-(4-methoxyphenyl)—6-bromo-3(H)-quinazolin-4-one ligand called HAMQ (HL9) was studied. To prepare this ligand anthranilic acid was converted into 5-bromo–N-Chloroacetyl anthranilic acid then into 2-chloromethyl–3-(4-methoxyphenyl)-6-bromo-3(H)-quinazoline-4-one. This compound was finally condensed with 5-amino-8-hydroxyquinoline. The transition metal complexes of Cu2+, Ni2+, Zn2+, Mn2+ and Co2+ of this ligand HAMQ were prepared and characterized by reflectance, NMR as well as IR spectroscopy, elemental analysis and magnetic measurements. The stoichiometry of the complexes has been found to be 1: 2 (Metal: ligand). The data suggested an octahedral geometry around Co2+, Ni2+ and Mn2+ complexes, a distorted octahedral geometry around Cu2+ and a tetrahedral geometry around Zn2+ have been proposed. These complexes have been tested for their antifungal activities.

These six are named as Satbhava padartha by Vaishishika darshan. Among these Satpadarthas Samanya and Vishesha are the two main principles of Ayurveda. Fundamental principles are the main pillars of Ayurvedic medicinal therapy. Principle of Vishesha is also one of these valuable principles. Vishesha is meant for diminution of all Vitiated, all existing materials. Cakrapani explained in his commentary that Vishesha is a differentiating intelligence. A disease can only be developed either by Vriddhi or Kshaya of natural Doshas. If we want to treat any disease, we have to either elevate or diminish these vriddha or Kshayit doshas to get equilibrium which is the main line of treatment in Ayurveda. Concept of Vishesha has been extracted from Vaisheshik Darshan. Maharishi Kanad has described Vishesha as one of the “sat-padarthas”. These “sat-padarthas” are to get abhyudaya i.e. prosperity in life and nishreyasa i.e. ultimate goal. Carak has firstly described the applied concept of Vishesha in Carak samhita. While commenting on Carak samhita acharya Cakrapani described the three types of Vishesha as Dravya Vishesha, Guna Vishesha, and Karma Vishesha. The concept of Vishesha siddhant can be applied in any type of disease which can occur due to vitiation of Doshas. Charmekeela is the growth like formation on the external surface of Twacha due to Prakupit vyanvayu along with Kapha and has been taken as trial disease in this study. To fulfill the objectives of study patients of Charmakeela attending the opd of skin care unit, R.G.G.P.G.Ay.college,Paprola,H.P. were selected and were divided into two groups.In group 1 decoction of Lekhniya mahakashaya in the the dose of 40 ml twice a day was given and in group 2 decoction of Lekhniya mahakashaya 40 ml along with local application of Apamarga pratisarniya kshara was done. Total duration of trial was 1 month. Patients were asked to come at every 15 days for follow up. Group2 has shown the markedly improvement in the cardinal symptoms of Charmakeela rather than group1. There was no significant change in hematological profile and lipid profile other than serum cholesterol of the patients before and after the trial. Decrease in serum cholesterol was significant before and after the trial.